Well, what happens is, the ladder bars change the arc at which the rear axle travels. So the ladder bars and leaf springs will bind without either eliminating the leaf springs and going to coil overs or adding the leaf spring floaters as 67 B-Body mentioned. At least that's my understanding. I've never had a reason to run ladder bars. I know they work, but when there are cars running in the 8s at over 160 MPH with leaf springs, I just never saw a point. Again, not that they won't work properly set up......I'm just not sure you can just bolt them on with leaf springs and go. I could be wrong.
Another thing to consider is you will lose some of the independence that the leaf springs offer. In other words, with ladder bars, when one side squats or rises, it will take the other side with it, where as with leaf springs, there is some independence from one side to the other. ...and I'm not sure that's necessarily a bad thing, but it's something else to consider.