Properly maintained, all of the old Mopar engines are extremely durable. My family has collected mopars since the late 60s, starting with my grandpa who used them on rural mail routes because the drivetrain and brakes stood up so much better than other vehicles, and they were cheap. He had several slant 6 valiants and volares that would last about 300k miles on the mail route before the body rusted away, engine and transmission still running like new. 904s and 727s didn't seem to have much difference behind a slant, unless it had a lockup converter which was unreliable. His main road transportation for 20 years was a 318 in a 1981 R-body gran fury cop car which I still drive to this day, 175k on it and no drivetrain issues, everything is original, even the lockup converter. My dad also owned an R body 1979 new yorker with a 360 that he used as daily transportation for over 10 years, it never gave any trouble until he sold it. Dad's Coronet R/T was his daily driver in the 70s and went 70k with no issues until it sat for 36 years and mice ruined the valves. He had countless new yorkers with 440s that never gave trouble, pulled the engines and built race motors out of them that he still runs today in his 70 cuda. He put one in a dodge truck and pulled his race cars countless miles to races every weekend. I recently dug a C body gran fury police car out of his junkyard that has a 400 with 138k miles now, it runs and drives extremely well after it sat for so long.
If you know how to take care of a car, an old chrysler will last a very long time. Change the oil and filter every 2-3 thousand miles with a good quality zddp oil and reputable filter, run at least midgrade fuel, run a stacked transmission cooler and engine oil cooler, and let the oil get up to temp before driving aggressively or shutting the engine off.