I just converted my '71 Charger to E-85. It gas a 499" stroked 400 block, around 12.3:1 compression. I was running race gas at $8.50/gallon, and the gas station near my house has E-85 for $1.99/gallon, but When I tested the E-85 fuel, it was only about 80%. The fuel station near a friends house tested at 85%, but they were a bit more expensive.
Anyhow, my point is you need to check the alcohol content as it changes between winter/summer blends and different stations, so it can affect your jetting.
I just have the Indy single plane 4150 intake, so I am using a Quick Fuel 1050cfm E-85 carb. Out of the box it was pretty rich running, but I am at 6,000 ft altitude.
I only have the carb on a few weeks and I am still tuning it, but so far no complaints.