I am going through this right now on a 383 with lower compression. I have a 750 Edlebrock and just purchased a 650 Edelbrock Thunder. The 750 was in my opinion running a little rich/rough at idle, but otherwise was ok with plenty of power. Alot of opinions are that a 750 is too big for a 383, which led me to try a 650. I put on the 650 and immediatly noticed a better idle, and throttle response from 1000-3000 rpm. But my wot went from easily smoking the tires in 1st for ever and then in 2nd for 10 feet to 10 feet in 1st with the 650. Big difference-but I bet I'm getting better mpg lol. So I called Edelbrock and talked to a tech for 1/2 hour. This was a very good conversation and I learned alot. He said either carb will work fine and a 750 is not too big for a 383. You have to decide if you want more top end power or a better responsive low end. You cannot easily change the idle jets on the 750 (they need to be soldered shut and redrilled smaller). So what he recommended is changing the secondary jets +.02 and metering rods one size up on the 650. This will keep my low end the same but should give more power at 30% to wot. Although he said it is not possible to make a 650 into a 750. Anyway I am picking up the parts today and hope to try them this weekend.