I once ( in the 70s) had a Trans Am, 4-speed with a lightly built motor that I put a 3.73 in. I had something like 255 or 275/60s on the rear at the time. I remember believing back then that this is a perfect rear gear ratio. Strong acceleration, drive lower speeds in any gear. Didn’t seem to buzzy or stressed on the highway. But that was with a 4-speed. My 67 GTX is an auto with a little higher than stock - stall converter. Its a little busy on even 60 mph roads and if I did any serious highway driving I would not go numerically higher than a 3.55 with an auto and non-stock converter. But that’s just me at 71 now.