IMHFO the biggest problem I see, is most people are clueless on effects of fuel or any gasoline additive or alcohol in your fuel system, how to prevent problems, caused by water or condensation or even corrosion/rusting in your fuel system, even rubber deterioration, from using these products like Algae, Sugar Cane, Corn/Grain or Wood Alcohols, like E85/Ethanol or a form of Methanol or many of the other harmful fuel supplements/additives, that are supposed to be a flex fuel or better for the environment, that can cause harmful issues, if not treated or maintained properly... the Un-educated masses, is the real problem.... along with the federal govt. mandating this type stuff, in many parts of the US, with out doing the proper research, of effects & causes, because of some shady/corrupt green party environmentalist affiliations or DC corn or grain lobbyists, money grab, pushing their products & having them forced on the un-educated general public...
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also lean/fuel ratio issues &/or other fuel related govt. subsidized, not proprerly tested, before they're marketed type products...