The six pack flows well for what it is. The 1350 CFM rating is at the 2bbl. rating which equals some where around just under 950 CFM as a 4bbl. rated carb. I forget the exact conversion number. What does your engine require?
The next item in the A&F path is the intake manifold as perviously mentioned. The statement is correct! The intake needs to flow better than the heads. I have read before that the 6 pack intake can flow up around 300cfm when lightly ported.
If your heads out flow the intake, a change is in order for maximizing performance.
Taking it to the max is something you will have to decide. It's not a must but a bennifit to do so. And only you will know.
Lastly, the engine itself! Cubic inch aside, what the engine will need in terms of A&F to feed it is a engine combo related issue no matter the size of the engine. After all, you could build a low rpm 500 or a big rpm 400 that both will use or out strip the manifolds ability. It is the engines demand for air and at what rpm you expect to be turning it at.
A 500 will consume more, quicker at a lower rpm than a 400 otherwise equally built. Even though the intake has a 2500-6500 operating rpm range, you could use it up earlier in a 500 or just simply run out of intake manifold with a high winding 400.
Also mentioned above, with bigger hp engines, the move to a single plane and carb becomes the "What's needed" for that application. If your going to bud the 6 pack regulardless, you may have to back down on aggressive cam timing and reduce the expect Hp output level for a well balanced and running engine, which would be a lot better and nicer to drive than a over cammed pig that can breath where it count and is wanted most.
MoPar used to have a "Tip" section where the 6 pack is used to run in the 11's.
Is this E.T. good for you?