I will share my situation for a bit of reference. I have a 68 Coronet Station Wagon that weighs about 4,000 lbs. It had a 318 with a very mild hyd cam, 4 bbl carb, 2.76 gear and a 904 transmission. I got 17 mpg on when I drove from NY to Florida (approx. 1,000 miles). This was with 27" tires. I swapped in a 390 (318 stroker), added EFI and 28.5" tires with the same 2.76 rear gear. I now get 12 - 13 mpg Highway. The 390 has a mild hyd roller cam. I imagine she weighs about the same as I went from steel wheels to aluminum during the engine swap. I was surprised at the difference but cubic inches burn fuel. My next move is an A500 overdrive transmission and a Gen III Hemi and 3.23 gears. I will be happy if I get high teens but that will be with premium fuel. So Its a push as far as fuel costs. But she'll have about 500 hp with the Hemi. Do you know your vehicle weight?