As l mentiomed previously, I'm totally aware how a carb operates, its various circuits including the ones you mentioned, for Carter, Holley, Rochester, Motorcraft/Ford, Weber, etc.
When driving at highway speeds on cruise control (if equipped), one assumes the temperature and barometric pressure (Manifold Absolute Pressure which is the inverse of vacuum) are the same, as that effects air density and ultimately the A/F ratio the engine produces.
Probably, the most difficult circuit in a carb to "adjust" is the idle transition circuit, which functions ftom idle thru the main fuel feed system, as the are no true adjustable components involved.....omly fixed air bleeds, fixed fuel feed and the transfer slots in the primary throttle bores. The primary (and secondary) fuel emulsion tubes or channels also influence the mixture density and ultimately the A/F ratio becsuse of their effect on the burn rate of the fuel charge. Cam specs, compression ratio, spark advance characteristics (rate of change) also can infuence the A/F ratio as well. Static A/F ratios (single point) are nice to know but the best systems are the ones that electronically adjustable....i.e. fuel injection systems that use 02 trim to maintain the optimal A/F ratio for a given engine option.