Funny, because Don at Four Seconds Flat insists on manifold vacuum as the source for ignition advance, and as anyone who knows him won't be surprised to hear, offers a very "forceful" explanation of the reasons why.
I switched over my ignition system from a Chrysler electronic version to the "pre-tuned" FBO setup, using their proprietary control box w/multiple spark output and an excellent rev limiter. Bypassed the ballast resistor and changed out the ignition coil to a Flamethrower III. There were other changes made, like careful, "enlightened" 6bbl carb tuning, and I had to plumb in a vacuum fitting in a pre-existing threaded hole in the rear of the Edelbrock aluminum 6bbl intake. The old vacuum advance used a ported source that had been eliminated when I had the Promax center carb metering block and other parts installed.
Anyway, everything came together and my engine no longer smelled like a refinery or made my eyes water, the idle improved greatly, and so on.
I'm 99% sure my much anticipated Progression Ignition system also uses manifold vacuum for its advance calculations.