Yes I have. I am using a Holley Sniper in tank pump ((Walbro 255 lpm) fed with 3/8" line to a return regulator set at 6.5psi into a 800cfm Edelbrock AVS2 (dual feed 3/8" lines from regulator).
My first return line was 1/4" because that is what I had. Way too small and overpowered the regulator (Aeromotive, I believe) resulting in high pressure and carb flooding. I called Holley and they said 3/8" in and 3/8" out. Nothing smaller. Did it and the pressure has been rock steady.
May be different results with a external pusher pump like the Holley Black, etc.
The Sniper has its own built-in regulator. It’s preset at 58.5 PSI. They recommend a minimum 3/8 fuel line for feed and return line.